The Physicians Committee for Responsible Medicine (Washington, D.C.;
www.pcrm.org), the Medical Research Modernization Committee (Cleveland, Ohio; www.mrmcmed.org), and Europeans for Medical
Progress (London, U.K., www.curedisease.net) combined have over 12,000
physician and scientist members, most of whom are highly critical of animal
Barnard ND, Kaufman SR. Animal research is wasteful and misleading. Scientific American 1997; Feb: 80-82.
Research Defense Society. Medical Advances and Animal Research.
Botting JH, Morrison AD. Animal research is vital to medicine. Scientific American 1997; Feb: 83-85.
Reines BP. On the locus of medical discovery. Journal of Medicine and Philosophy 1991; 116: 183-209.
Reines BP. On the role of clinical anomaly in Harvey's discovery of the
mechanism of the pulse. Perspectives in
Biology and Medicine 1990; 34: 128-133.
McQuarrie I. The Experiments of Nature
and Other Essays from the Porter Lectures. Lawrence, Kansas, University of
Kansas Press, 1944.
Beeson PB. The growth of knowledge about a disease: hepatitis. American Journal of Medicine 1979; 67:
Good RA. Runestones in immunology. Journal
of Immunology 1976; 117:1413-1428.
Good RA. Keystones. Journal of Clinical Investigation 1968; 47:1466-1471. [Beeson and Good have emphasized that they consider animal
experimentation it important to medical progress. However, their articles demonstrate
the primacy of human clinical investigation.]
Greek CR, Greek JW. Specious Science. New York, Continuum, 2002.
Brecher R. The Consumers Union Report on
Smoking and the Public Interest. Mount Vernon, Consumers Union, 1963.
Northrup E. Men, mice, and smoking, in Science
Looks at Smoking. New York, Coward-McCann, 1957, p 133.
Enterline PE. Asbestos and cancer, in Gordis L (ed). Epidemiology & Health Risk Assessment. New York, Oxford
University Press, 1988.
Gardner MJ, Snee MP, Hall AJ, et al. Results of case-control study of leukaemia
and lymphoma among young people near Sellafield nuclear plant in West Cumbria. British Medical Journal 1990; 300:423-429.
Stewart A. Alternative sources of risk estimates for cancer effects of
radiation. The Mount Sinai Journal of
Medicine 1995; 62:380-385.
Gould JM, Sternglass EJ. Nuclear fallout, low birthweight, and immune
deficiency. International Journal of
Health Science 1994; 24:311-335.
Bross ID. Fifty Years of Folly and Fraud "In the Name of Science."
Buffalo, Biomedical Metatechnology, 1994.
HJ. Victory with Vaccines. Edinburgh
and London, E&S Livingstone Ltd., 1968.
Paul JR. History of Poliomyelitis. New Haven, Yale University Press, 1971.
Sabin AB. Statement of Albert B. Sabin, M.D. Hearing before the Subcommittee on
Hospitals and Health Care of the Committee on Veterans' Affairs of the House of
Representatives, April 26, 1984, serial no. 98-48.
Enders JF, Weller TH, Robbins FC. Cultivation of the Lansing strain of
poliomyelitis virus in cultures of various human embryonic tissue. Science 1949; 109:85-86.
Domingo RT, Fries C, Sawyer P, Wesolowski S. Peripheral arterial
reconstruction. Transplantation of autologous veins. Transactions of the American Society of Artificial Internal Organs 1963; 9:305-316.
Hume D. Experiences with renal homotransplantation in the human subject. Journal of Clinical Investigation 1955;
Bailar JC III, Gornik HL. Cancer undefeated. New England Journal of Medicine 1997; 336:1569-1574.
Dulbecco R. A turning point in cancer research: Sequencing the human genome. Science 1986; 231:1055-1056.
Leavitt J. The case for understanding the molecular nature of cancer: Some
recent findings and their implications. Medical
News Sept 9, 1985.
Bross I. Crimes of Official Science. Buffalo, Biomedical Metatechnology, 1987.
Hahn WC, Counter CM, Lundberg AS, Beijersbergen RL, Brooks MW, Weinberg RA.
Creation of human tumour cells with defined genetic elements. Nature 1999; 400:464-467.
30. Cimons M,
Getlin J, Maugh II, TH. Cancer drugs face long road from mice to men. Los
Angeles Times, May 6, 1998.
31. Anderson ER, Xiong
H, Gendelman HE. Animal Model Systems of HIV-Diseases, in Friedman H, Specter
S, Bendinelli M, In Vivo Models of HIV Disease and Control.
Berlin, Springer-Verlag, 2006.
Mitsuya H, Weinhold KJ, Furman PA, et al. 3'-Azido-3'deoxythymidine (BS A509U). Proceedings of the National Academy of
Sciences USA 1985; 82:7096-7100.
H, Yao X-J, Gao Q, et al. Anti-human immunodeficiency virus type 1 activity and in vitro toxicity of
2'-deoxy-3'-thiacytidine (BCH 189), a novel heterocyclic nucleoside analog. Antimicrobial Agents and Chemotherapeutics 1991; 35:1386-1390.
Roberts NA, Martin JA, Kinchington D, et al. Rational design of peptide-based
HIV proteinase inhibitors. Science 1990: 248;358-361.
35. Bailey J. An assessment of the role of chimpanzees in AIDS vaccine
research Alternatives to Laboratory Animals 2008; 36:381-428.
36. Esparza J. A brief history of the global effort to develop a
preventive HIV vaccine. Vaccine 2013; 31:3502-18.
Zbinden G, Flury-Roversi M. Significance of the LD50 test for the toxicological
evaluation of chemical substances. Archives
of Toxicology 1981; 47:77-99.
Fano A. Lethal Laws: Animal Testing,
Human Health and Environmental Policy. London, Zed Books, 1997, pp 157-159.
Stephens M. Replacing animal experiments, in Langley G (ed). Animal Experimentation: The Consensus
Changes. New York, Chapman and Hall, 1989, pp 144-168.
Lave LB, Ennever FK, Rosenkranz HS, Omenn GS. Information value of the rodent
bioassay. Nature 1988; 336:631-633.
J, Knight A, Balcombe J. The future of teratology
research is in vitro. Biogenic Amines, 2005; 19 (2):97-145.
42. Coleman RA.
Human-based systems in drug and chemical safety testing – toward replacement, the ‘single R’. Alternatives to Laboratory Animals 2014;
43. Kenna J G.
Human biology-based drug safety evaluation: scientific rationale, current
status and future challenges. Expert
Opinion on Drug Metabolism and Toxicity 2017; 13:567-574
LaFollette H, Shanks N. Animal models in biomedical research: Some
epistemological worries. Public Affairs
Quarterly 1992; 7:113-130.
LaFollette H, Shanks N. Brute Science. New York, Routledge, 1997.
Kaufman SR, Reines BP, Casele H, Lawson L, Lurie J. An evaluation of ten
randomly chosen animal models of human diseases. Perspectives on Animal Research 1989; 1 (Suppl): 1-128.
Kaufman SR, Czarnecki T, Haralabatos I, Richardson M. Animal models of
degenerative neurological diseases. Perspectives
on Medical Research 1991; 3:9-48.
Smith CD. A critique of brain wound research. Perspectives on Animal Research 1989; 1:19-24.
Buyukmihci NC. Response to Dr. Blakemore's assertion that work involving
nonhuman animals has led to significantly greater understanding and treatment
of amblyopia. Perspectives on Animal
Research 1989; 1:57-62.
Cohen MJ, Black DN, Fouts RS, Dobbs FW. A critique of neurology experiments at
Northwestern University. Perspectives on
Medical Research 1993; 4:22-28.
Kaufman SR. Animal models of spinal cord injury. Perspectives on Medical Research 1990; 2:1-12.
Mack JD, Greenberg RA. Review of scoliosis research at the University of
Michigan. Perspectives on Medical
Research 1990; 2:33-36.
Committee on Animal Models in Biomedical Research. Aping Science. Medical Research Modernization Committee, New York,
55. Bailey J.
Monkey-based research on human disease: the implication of genetic differences. Alternatives to Laboratory Animals 2014; 42:287-317.
56. Bailey J.
Lessons from chimpanzee-based research on human disease: the implications of
genetic differences. Alternatives to
Laboratory Animals 2011; 39:527-40.
57. Greek R,
Menache A. Systematic Review of Animal Models: Methodology versus Epistemology. International Journal of Medical Sciences 2013; 10:206-221.
Peller S. Quantitative Research in Human
Biology and Medicine. Bristol, England, John Wright & Sons, 1967.
Hewitt HB. The use of animals in experimental cancer research, in Sperlinger D
(ed). Animals in Research. New York,
John Wiley & Sons, 1981.
Freedman DA, Zeisel H. From mouse to man: The quantitative assessment of cancer
risks. Statistical Science 1988; 3:3-28.
Smith CD. Head injury research at the University of Cincinnati. Perspectives on Animal
Research 1989; 1:9-18.
Ames BN, Gold LS. Too many rodent carcinogens: Mitogenesis increases
mutagenesis. Science 1990; 249:970-971.
Wiebers DO, Adams HP, Whisnant JP. Animal models of stroke: Are they relevant
to human disease? Stroke 1990; 21:1-3.
Habal MB. The influence of lip repair with and without soft-tissue undermining
on facial growth in beagles [discussion]. Plastic
and Reconstructive Surgery 1988; 82:756-759.
Fernandes D. Animal experimentation: Necessary or not? Cleft Palate Journal 1989; 26:258.
66. Sutherland BA,
Minnerup J, Balami JS, et al. Neuroprotection for ischaemic stroke: translation
from the bench to the bedside. International
Journal of Stroke 2021; 7:407-18.
67. Seok J, Warren
HS, Cuenca AG, et al. Genomic responses in mouse models poorly mimic human
inflammatory diseases. Proceedings of the
National Academy of Sciences 2013; 110:3507-12.
68. Mullane K,
Williams M. Translational semantics and infrastructure: another search for the
emperor’s new clothes? Drug Discovery
Today 2012; 17:459-468.
Barnard ND, Hou S. Inherent stress: The tough life in lab routine. Lab Animal Sept 1988, pp 21-27.
JP, Barnard ND, Sandusky C. Laboratory routines cause animal stress. Contemporary Topics 2004; 43: 42-51.
Greek CR, Greek JW. Sacred Cows and
Golden Geese. New York, Continuum, 2000.
M, Carver JR, Rodeheffer RJ, et al. Effect of oral milrinone on mortality in severe chronic heart failure. New England Journal of Medicine 1991;
73. McKenzie R, Fried MW, Sallie R,
et al. Hepatic failure
and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside
analogue for chronic hepatitis B. New
England Journal of Medicine 1995; 333:1099-1105.
Kolata G. 2 top diet drugs are recalled amid reports of heart defects. New York Times Sept 16, 1997, p A1.
J. Estrogen Research:
The great estrogen conundrum. Science, 2003; 302:1136-1138.
EJ. Failing the public
health – Rofecoxib, Merck, and the FDA. New England Journal of Medicine 2004; 351:1707-1709.
Bhogal N, Combes R. TGN1412: time to change the paradigm for the testing of new
pharmaceuticals. Alternatives to
Laboratory Animals 2006; 34:225-239.
Lazarou J, Pomeranz BH, Corey PN. Incidence of adverse drug reactions in
hospitalized patients. Journal of the
American Medical Association 1998; 279:1200-1205.
Cohen SM, Ellwein LB. Cell proliferation in carcinogenesis. Science 1990; 249:1007-1011. 80. Factors Affecting Drug
84. Geerts H. Of mice and
men: bridging the translational disconnect in CNS drug discovery. CNS Drugs. 2009; 23:915-26.
85. Jankovic J,
Noebels JL. Genetic mouse models of essential tremor: are they essential? J
Clin Invest. 2005; 115:584-586.
86. Kieburtz K,
Olanow CW. Translational experimental therapeutics: The translation of
laboratory-based discovery into disease-related therapy. Mt Sinai Journal of
Med. 2007; 74:7-14.
87. Liu Z, Maas K,
Aune TM. Comparison of differentially expressed genes in T lymphocytes between
human autoimmune disease and murine models of autoimmune disease. Clin
Immunol. 2004; 112:225-230.
88. Lindle T,
Volkel M, Kolar R. [Animal experiments in biomedical research. An evaluation of
the clinical relevance of approved animal eperimental projects] (in German) ALTEX 205; 22:143-151.
89. Hackam DG.
Translating animal research into clinical benefit: poor methodological
standards in animal studies mean that positive results may not translate to the
clinical domain. British Medical Journal 2007; 334:163-164.
90. Arrowsmith J. A decade of change. National Review of Drug Discovery 2012;
91. Hartung T. Food for thought look back in anger – what clinical
studies tell us about preclinical work. ALTEX 2013; 30:275-91. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790571/
92. U.S. General Accounting Office. FDA Drug
Review: Postapproval Risks 1976-1985. Publication
GAO/PEMD-90-15, Washington, D.C., 1990.
Lifton RJ. The Nazi Doctors. New
York, Basic Books, 1986.
Barber B. The ethics of experimentation with human subjects. Scientific American 1976; 234(2):25-31.
Eilperin J. EPA using data from chemical tests on humans. Washington Post, June 17, 2005, p A03.
Cole LA. The Eleventh Plague: The Politics of Biological and Chemical Warfare.
New York, W.H. Freeman & Company, 1996.
Kiernan V. Radiation doctors abused trust in the name of science. New Scientist Oct 14, 1995, p 8.
Annas GJ. Baby Fae: The "anything goes" school of human
experimentation. Hastings Center Report 1985; 15(1):15-17.
Preston R. The Hot Zone. New York,
Random House, 1994.
Cohen MJ. Ebola Alice? Texas Republic 1996; 3(2):27-30.
McKenna MAJ. Monkey virus kills Yerkes researcher. Atlanta Journal-Constitution Dec 12, 1997.
Pennisi E. Monkey virus DNA found in rare human cancers. Science 1997; 275:748-749.
Baboon cells fail to combat AIDS. Nature 1996;
Hooper E. The River: A Journey to the
Source of HIV and AIDS. Boston, Little, Brown & Co, 1999.
Reinhardt V, Roberts A. The African polio vaccine-acquired immune deficiency
syndrome connection. Medical Hypotheses 1997; 48:367-374.
Horowitz LG. Emerging Viruses: AIDS and
Ebola. Rockport, Mass, Tetrahedron, 1996.
Heimlich HJ, Patrick EA. The Heimlich maneuver: Best technique for saving any
choking victim's life. Postgraduate
Medicine 1990; 87:68-79.
Dole VP. On the relevance of animal models to alcoholism in humans. Alcoholism Clinical and Experimental
Research 1986; 10:361-363.
Cohen MJ, Young C. "Alcoholic"
Rats and Other Alcohol Research Using Animals. New York, National Research
Information Center, 1989.
Sitaram N, Gershon S. Animal models to clinical testing – promises and
pitfalls. Progress in
Neuropsychopharmacology, Biology and Psychiatry 1983; 7: 227-228.
Davis JM. Antipsychotic drugs, in Kaplan HI, Sadock BJ (eds). Comprehensive Textbook of Psychiatry, Fourth
Ed. Baltimore, William and Wilkins, 1985.
Pearson OH, Eliel LP, Rawson RW, et al. ACTH- and cortisone-induced regression
of lymphoid tumors in man. Cancer 1949;
Boesen E. Cytotoxic Drugs in the
Treatment of Cancer. London, Edward Arnold, 1969, p 24.
Coley WB. A preliminary note on the treatment of inoperable sarcoma by the
toxic product of erysipelas. The
Post-Graduate 1893; 8:278-286.
Caldwell A. Origins of
Psychopharmacology: From CPZ to LSD. Springfield, Charles C Thomas, 1970.
Lehmann HE, Kline NS. Clinical discoveries with antidepressant drugs, in
Parnham MJ, Bruinvels J (eds). Discoveries
in Pharmacology, Volume 1. New York, Elsevier, 1983, pp 209-221.
Sulser F, Mishra R. The discovery of tricyclic antidepressants and their mode
of action, in Parnham MJ, Bruinvels J (eds). Discoveries in Pharmacology, Volume 1. New York, Elsevier, 1983, pp
118. Unal B
et al. Modelling the decline in coronary
heart disease deaths in England and Wales, 1981-2000: comparing contributions
from primary prevention and secondary prevention. British
Medical Journal 2005; 331:614.
119. Doll R
et al. Mortality in
relation to smoking: 50 years' observations on male British doctors. British Medical Journal 2004; 328:1519.
120. Ambrosonel CB, Harris CC. The development of molecular epidemiology to
elucidate cancer risk and prognosis: a historical perspective. International Journal of Molecular Epidemiology
and Genetics 2010; 1(2):84-91 www.ijmeg.org/files/IJMEG1002001.pdf.
Esselstyn Jr. CB. Updating a 12-year experience with arrest and reversal
therapy for coronary heart disease. American
Journal of Cardiology 1999; 84: 339-341.
Ornish D, for the Multicenter Lifestyle Demonstration Project Research Group.
Avoiding revascularization with lifestyle changes: The multicenter lifestyle
demonstration project. American Journal
of Cardiology 1998; 82:72T-76T.
Heimlich HJ. Advantages and safety of clinical research, in Cohen M, Natelson N
(eds). Facing the Challenge. Alexandria VA, Concern for Helping Animals in Israel, 1990, pp 123-135.
Savoy RL. History and future directions of human brain mapping and functional
neuroimaging. Acta Psychologica 2001;
125. Farwell MD, Pryma DA, Mankoff DA. PET/CT imaging in
cancer: Current applications and future directions. Cancer 2014; 120:3433–3445.
Hill RB, Anderson RE. The Autopsy:
Medical Practice and Public Policy. Boston, Butterworth, 1988.
Opie EL. Disease of the Pancreas. Philadelphia, JB Lippincott, 1910.
Barron M. The relation of the islets of Langerhans to diabetes with special
reference to cases of pancreatic lithiasis. Surgery,
Gynecology and Obstetrics 1920; 31:437-448.
Ahnen DJ. Are animal models of colon cancer relevant to human disease? Digestive Diseases & Sciences 1985;
30 (12 Suppl):103S-106S.
Pories SE, Ramchurren N, Summerhayes I, Steele G. Animal models for colon
carcinogenesis. Archives of Surgery 1993; 128:647-653.
C, Bunton D. Could fresh human tissues play a key role in drug development. Alternatives to Laboratory Animals 2009;
Stevens C. Statement before the House Subcommittee on Labor, Health and Human
Services, April 30, 1987.
Pihl A. UICC Study Group on chemosensitivity testing of human tumors. Problems
– applications – future prospects. International Journal of Cancer 1986; 37:1-5.
Gura T. Systems for identifying new drugs are often faulty. Science 1997; 278:1041-1042.
Anon. Drug discovery screen adapts to change. Journal of the National Cancer Institute 1990; 82:1087.
136. Tsukamoto T.
Animal disease models for drug screening: the elephant in the room? Drug
Discov. Today 2016; 21:529-530.
137. Giri S, Bader
A. A low-cost, high-quality new drug discovery process using patient-derived
induced pluripotent stem cells. Drug Discovery
Today 2015; 20:37-49.
138. Pound P,
Bracken MB. Is animal research sufficiently evidence based to be a cornerstone
of biomedical research? British Medical
Journal 2014; 348:g3387.
139. Langley GR,
Adcock IM, Busquet F, et al. Towards a 21st-century roadmap for
biomedical research and drug discovery: consensus report and recommendations. Drug Discovery Today 2017;22:327-339.
Hendriksen CFM. Laboratory Animals in
Vaccine Production and Control: Replacement, Reduction and Refinement. Boston, Kluwer Academic Pub, 1988.
141. Metz B, Hendricksen CF,
Jiskoot W, Kersten GF. Reduction
of animal use in human vaccine quality control: opportunities and problems. Vaccine 2002; 20:2411-30.
Hayflick L. The choice of the cell substrate for human virus vaccine
production. Laboratory Practice 1970;
Beale AJ. Use of tissue cultures for testing vaccines. Journal of the Royal Society of Medicine 1978; 71:681-686.
Hayflick L. Human virus vaccines: Why monkey cells? Science 1972; 176:183-184.
G, Noveck R, Burt T. Microdosing and drug development: past, present and
future. Expert Opin Drug Metab Toxicol 2013; 9:817-834. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532546/.
Yevale R, Khan N, Jagtap P, et al. A review on microdosing: Reduction in Cost
& Time. International Journal of
Pharmacy & Pharmaceutical Research 2016; 6:325-330.
Bazell RJ. Smoking dogs: Tobacco institute tries to discount cancer studies. Science 1970; 170:515.
Auerbach O, Hammond EC, Kirmian D, Garfinkel L. Effects of cigarette smoking on
dogs II. Pulmonary neoplasms. Archives of
Environmental Health 1970; 21:754-768.
Gluck JP, Kubacki SR. Animals in biomedical research: The undermining effect of
the rhetoric of the besieged. Ethics and
Behavior 1991; 2:157-173.
Weibers DO, Leaning J, White RG. Animal protection and medical science. The Lancet 1994; 343: 902-904.
Kaufman SR. Animal protection and medical science [letter]. The Lancet 1994; 343:1574.
Dunayer J. Censored: Faculty who oppose vivisection. Z Magazine, April 1993, pp. 57-60.
Arluke A. The ethical socialization of animal researchers. Lab Animal June 1994, pp 30-35.
Moore EJ. Animal Experiments [letter]. The
Lancet 1986; 1 (8487): 975.
Phillips M. Savages, drunks and lab
animals: The researcher's perception of pain. Society and Animals 1993; 1:61-81.
DA. Antivivisection [letter]. British
Medical Journal 1983; 286 (6381):1894.
Rowan AN. Is justification of animal research necessary? [letter]. Journal of the American Medical Association 1993; 269:1113-1114.
Buyukmihci NC. Consistency in treatment and moral concern. Journal of the American Veterinary Medical Association 1995; 206:477-480.
K. No need for monkeys [letter]. New
Scientist July 1, 2006, p 26.
Masson JM, McCarthy S. When Elephants
Weep: The Emotional Lives of Animals. New York, Delacorte Press, 1995.
Bekoff M. The Smile of a Dolphin. New
York, Discovery Books, 2000.
Balcombe, J. Second Nature: The Inner
Lives of Animals. New York, Palgrave Macmillan, 2010.
DJ et al. Social modulation of
pain as evidence for empathy in mice. Science 2006; 312 (5782):1967-1970.
166. Masserman JH, Wechkin S, Terris W. 1964. ‘Altruistic’ behavior in
rhesus monkeys. American Journal of
Psychiatry 1964; 121:584–585.
Fouts RS. Next of Kin. New York,
William Morrow, 1997.
Patterson F, Linden E. The Education of
Koko. New York, Rinehart & Winston, 1991.
American Medical Association. AMA White
Paper. Use of Animals in Biomedical Research: The Challenge and Response.1988.
U.S. Department of Agriculture. 2002 Farm Bill Amendment Section on Rats, Mice,
and Birds. www.aphis.usda.gov/ac/farmbill2002.html.
171. Pew Research
Center. Americans, Politics and Science
Issues, Chapter 7: Opinion about the Use of Animals in Research. July 1,